| 货号 | 13027-50mg |
| 描述 | Physostigmine is a natural, reversible cholinesterase (ChE) inhibitor that inhibits both acetyl ChE and butyryl ChE (IC50s = 28 and 16 nM, respectively).1,2 ChE inhibitors, including physostigmine, have potential value in ameliorating dementia associated with neurodegenerative diseases.3,4,5,6 |
| 别名 | Eserine;MCV 4484;NIH 10421;NSC 30782;(-)-Physostigmine; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Yu, Q.S.,Zhu, X.,Holloway, H.W., et al. Anticholinesterase activity of compounds related to geneserine tautomers. N-oxides and 1,2-oxazines. J. Med. Chem. 45(17), 3684-3691 (2002). 2.Luo, W.,Yu, Q.S.,Kulkarni, S.S., et al. Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (−)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J. Med. Chem. 49(7), 2174-2185 (2006). 3.Christie, J.E.,Shering, A.,Ferguson, J., et al. Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. British Journal of Psychiatry 138, 46-50 (1981). 4.Baskys, A., and Hou, A.C. Vascular dementia: Pharmacological treatment approaches and perspectives. Clinical Interventions in Aging 2(3), 327-335 (2007). 5.Grossberg, G.,Cummings, J.,Frölich, L., et al. Efficacy of higher dose 13.3 mg/24 h rivastigmine patch on instrumental activities of daily living in patients with mild-to-moderate Alzheimer’s disease. Am.J.Alzheimers Dis.Other Demen. 28(6), 583-591 (2013). 6.Possin, K.L.,Kang, G.A.,Guo, C., et al. Rivastigmine is associated with restoration of left frontal brain activity in Parkinson’s disease. Mov.Disord. 28(10), 1384-1390 (2013). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 275.4 |
| 分子式 | C15H21N3O2 |
| CAS号 | 57-47-6 |
| 稳定性 | ≥ 2 years |
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