Daminozide
货号：
12033-5g 基本售价：
252.0 元 规格：
5 g
产品信息
概述| 货号 | 12033-5g |
| 描述 | Daminozide is a highly selective inhibitor of the human 2-oxoglutarate (JmjC) histone demethylases KDM2A, PHF8, and KDM7A with IC50 values of 1.5, 0.55, and 2.1 μM, respectively.1 When tested for inhibition of other demethylase subfamily members (KDM3, KDM4, KDM5, KDM6) and other 2OG oxygenases (FIH, PHD2, BBOX1), daminozide was considerably less potent (IC50s > 100 μM).1 Daminozide is known to retard plant growth and was widely used in the 1960s for agricultural and horticultural applications to control plant size and fruit ripening before it was withdrawn because of carcinogenicity concerns.2 |
| 别名 | Alar;Aminozide;B 995;DIMG;DMASA;Kylar;SADH;Succinic Acid; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Rose, N.R.,Woon, E.C.Y.,Tumber, A., et al. Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. Journal of Medicinal Chemistry 55, 6639-6643 (2012).
2.Rademacher, W. Growth retardants: Effects on gibberellin biosynthesis and other metabolic pathways. Annual Reviews of Plant Physiology and Plant Molecular Biology 51, 501-531 (2000).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 160.2 |
| 分子式 | C6H12N2O3 |
| CAS号 | 1596-84-5 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
