SB-505124
货号：
11793-1mg 基本售价：
252.0 元 规格：
1 mg
产品信息
概述| 货号 | 11793-1mg |
| 描述 | SB-505124 inhibits the TGF-β1 receptor serine/threonine kinase ALK5 with an IC50 value of 47 nM.1 Though it is a less potent antagonist of ALK4 (IC50 = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and TGF-β–induced MAP kinase pathway components without altering ALK1-3 or ALK6-induced SMAD signaling.1 In an assay determining in vitro phosphorylation of SMAD3, SB-505124 is more potent than SB-431452 (Item No. 13031) with IC50 values of 47 versus 94 nM, respectively.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.DaCosta, S.,Major, C.,Laping, N.J., et al. SB-505124 is a selective inhibitor of transforming growth factor- ß type I receptors ALK4, ALK5, and ALK7. Molecular Pharmacology 65, 744-752 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 335.4 |
| 分子式 | C20H21N3O2 |
| CAS号 | 694433-59-5 |
| 稳定性 | ≥ 2 years |
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