| 货号 | 11326-1mg |
| 描述 | Cyclopiazonic acid is a mycotoxin produced by molds including certain species of PenicilliumandAspergillus. Its toxicity is linked to its ability to specifically and reversibly inhibit sarco-endoplasmic reticulum Ca2+-ATPases (SERCA; IC50 = 0.6 μM).1,2 Cyclopiazonic acid does not inhibit a wide variety of other types of membrane-bound ATPases. It effectively inhibits SERCA in intact tissue, in smooth muscle and endothelium, as well as in isolated cells.3,4 |
| 别名 | NSC 117181; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Seidler, N.W.,Jona, I.,Vegh, M., et al. Cyclopiazonic acid is a specific inhibitor of the Ca2+-ATPase of sarcoplasmic reticulum. The Journal of Biological Chemisty 264(30), 17816-17823 (1989). 2.Uyama, Y.,Imaizumi, Y. and Watanabe, M. Effects of cyclopiazonic acid, a novel Ca2+-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. British Journal of Pharmacology 106, 208-214 (1992). 3.Mumtaz, S.,Burdyga, G.,Borisova, L., et al. The mechanism of agonist induced Ca2+ signalling in intact endothelial cells studied confocally in in situ arteries. Cell Calcium 49(1-4), 66-77 (2011). 4.Berra-Romani, R.,Raqeeb, A.,Torres-Jácome, J., et al. The mechanism of injury-induced intracellular calcium concentration oscillations in the endothelium of excised rat aorta. Journal of Vascular Research 49, 65-76 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 336.4 |
| 分子式 | C20H20N2O3 |
| CAS号 | 18172-33-3 |
| 稳定性 | ≥ 2 years |
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