TG003
货号：
10398-1mg 基本售价：
252.0 元 规格：
1 mg
产品信息
概述| 货号 | 10398-1mg |
| 描述 | Cdc2-like kinase (Clk), among a number of other kinases, phosphorylates serine/arginine-rich proteins which play a role in alternative splicing of pre-mRNA. The Clk family consists of four members, which include Clk1/Sty and Clk2-4. TG003 is a novel benzothiazole compound that demonstrates potent inhibition of Clk1/Sty and Clk4 with IC50 values of 20 and 15 nM, respectively.1 TG003 exhibits considerably weaker inhibition of Clk2 and Clk3 (IC50 = 200 nM and >10 μM, respectively).1 Through suppression of Clk-mediated phosphorylation, TG003 inhibits SF2/ASF-dependent splicing of β-globin pre-mRNA at 1 μM in vitro.1 At 10 μM, TG003 rescues the embryonic defects induced by excessive Clk activity in Xenopus.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Muraki, M.,Ohkawara, B.,Hosoya, T., et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. The Journal of Biological Chemisty 279(23), 24246-24254 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 249.3 |
| 分子式 | C13H15NO2S |
| CAS号 | 300801-52-9 |
| 稳定性 | ≥ 2 years |
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