| 货号 | 75770-1mg |
| 描述 | Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.1,2,3 MS-PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.4 MS-PPOH inhibits the formation of arachidonate 11,12-epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 13 µM, but has no effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.5 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Capdevila, J.H.,Karara, A.,Waxman, D.J., et al. Cytochrome P-450 enzyme-specific control of the regio- and enantiofacial selectivity of the microsomal arachidonic acid epoxygenase. The Journal of Biological Chemisty 265, 10865-10871 (1990). 2.Sacerdoti, D.,Abraham, N.G.,McGiff, J.C., et al. Renal cytochrome P-450-dependent metabolism of arachidonic acid in spontaneously hypertensive rats. Biochemical Pharmacology 37, 521-527 (1988). 3.Fitzpatrick, F.A. and Murphy, R.C. Cytochrome P-450 metabolism of arachidonic acid: Formation and biological actions of “epoxygenase”-derived eicosanoids. Pharmacological Reviews 40, 229-241 (1989). 4.Imig, J.D.,Falck, J.R. and Inscho, E.W. Contribution of cytochrome P450 epoxygenase and hydroxylase pathways to afferent arteriolar autoregulatory responsiveness. British Journal of Pharmacology 127, 1399-1405 (1999). 5.Wang, M.H.,Brand-Schieber, E.,Zand, B.A., et al. Cytochrome P450-derived arachidonic acid metabolism in the rat kidney: Characterization of selective inhibitors. Journal of Pharmacology and Experimental Therapeutics 284(3), 966-973 (1998). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 323.4 |
| 分子式 | C16H21NO4S |
| CAS号 | 206052-02-0 |
| 稳定性 | ≥ 2 years |
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