| 货号 | 12085-10mg |
| 描述 | Cladribine is an adenosine analog which shows selective cytotoxicity against both proliferating and non-dividing lymphocytes. Resistant to adenosine deaminase, cladribine is phosphorylated by deoxycytidine kinase, resulting in its intracellular accumulation and inhibition of ribonucleotide reductase.1,2 It inhibits lymphocyte growth with an IC50 value of 45 nM.3 The pharmacokinetics of clabridine in humans have been published.4 After only a single course of treatment, clabridine eradicates hairy cell leukemia.5 It has potential use in a variety of hematologic malignancies, but its use in treating multiple sclerosis is compromised by serious adverse events.6,7 |
| 别名 | Biodribin;2-Chlorodeoxyadenosine;Jk 6251;Leustatin;NSC 105014;RWJ 26251; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Tallman, M.S., and Hakimian, D. Purine nucleoside analogs: Emerging roles in indolent lymphoproliferative disorders. Blood 86(7), 2463-2474 (1995). 2.Seto, S.,Carrera, C.J.,Kubota, M., et al. Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes. Journal of Clinical Investigation 75, 377-383 (1985). 3.Huang, M.C.,Ashmun, R.A.,Avery, T.L., et al. Effects of cytotoxicity of 2-chloro-2-deoxyadenosine and 2-bromo-2-deoxyadenosine on cell growth, clonogenicity, DNA synthesis, and cell cycle kinetics. Cancer Research 46, 2362-2368 (1986). 4.Liliemark, J., and Juliusson, G. On the pharmacokinetics of 2-chloro-2-deoxyadenosine in humans. Cancer Research 51, 5570-5572 (1991). 5.Sigal, D.S.,Sharpe, R.,Burian, C., et al. Very long-term eradication of minimal residual disease in patients with hairy cell leukemia after a single course of cladribine. Blood 115(10), 1893-1896 (2010). 6.Sigal, D.S.,Miller, H.J.,Schram, E.D., et al. Beyond hairy cell: The activity of cladribine in other hematologic malignancies. Blood 116(16), 2884-2896 (2010). 7.Nicholas, R.,Giannetti, P.,Alsanousi, A., et al. Development of oral immunomodulatory agents in the management of multiple sclerosis. Drug Des.Devel.Ther. 5, 255-274 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 285.7 |
| 分子式 | C10H12ClN5O3 |
| CAS号 | 4291-63-8 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |