Doramapimod
货号：
10460-1mg 基本售价：
238.0 元 规格：
1 mg
产品信息
概述| 货号 | 10460-1mg |
| 描述 | The stress-activated p38 mitogen-activated protein kinase (MAPK) plays a critical role in regulating the production of proinflammatory cytokines such as tumor necrosis factor and interleukin-1. Doramapimod is a highly potent inhibitor of p38 MAPK with a Kd value of 0.1 nM that blocks TNFα release in LPS-stimulated THP-1 cells with an IC50 value of 18 nM.1 At 10 μM, doramapimod inhibits JNK2α2 in vitro, but at the low concentration necessary to inhibit p38 MAPK, it does not affect the phosphorylation of JNK substrates in cells.2,3 |
| 别名 | BIRB-796; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Pargellis, C.,Tong, L., and Churchill, L. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nature Structural Biology 9(4), 268-272 (2002).
2.Bain, J.,Plater, L.,Elliot, M., et al. The selectivity of protein kinase inhibitors: A further update. Biochemistry Journal 408, 297-315 (2007).
3.Kuma, Y.,Sabio, G.,Bain, J., et al. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. The Journal of Biological Chemisty 280(20), 19472-19479 (2005).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 527.7 |
| 分子式 | C31H37N5O3 |
| CAS号 | 285983-48-4 |
| 稳定性 | ≥ 2 years |
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