1-Arachidonoyl Glycerol
货号：
62150-1mg 基本售价：
224.0 元 规格：
1 mg
产品信息
概述| 货号 | 62150-1mg |
| 描述 | The glyceryl esters of arachidonic acid have been proposed as endogenous cannabinoid ligands.1 2-AG is 10 to 100 times more potent than 1-AG in ligand binding affinity and agonist activity at the CB1 receptor, and is thus considered to be the natural ligand.2 However, 2-AG is chemically unstable and undergoes rapid isomerization to 1-AG (synonymous with 1(3)-AG) both in vitroandin vivo. 1-AG is a frequent contaminant in synthetic 2-AG preparations, and can markedly reduce their cannabinergic potency. 1-AG is a weak CB1 receptor agonist and may have other pharmacologic properties. |
| 别名 | 1-AG; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Sugiura, T.,Kodaka, T.,Kondo, S., et al. 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma X glioma hybrid NG108-15 cells. Biochemical and Biophysical Research Communications 229, 58-64 (1996).
2.Sugiura, T.,Kodaka, T.,Kondo, S., et al. Is the cannabinoid CB1 receptor a 2-arachidonoylglycerol receptor? Structural requirements for triggering a Ca2+ transient in NG108-15 cells. Journal of Biochemistry 122, 890-895 (1997).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% (as a 9:1 mixture of the 1-AG and 2-AG) |
| 计算分子量 | 378.6 |
| 分子式 | C23H38O4 |
| CAS号 | 35474-99-8 |
| 稳定性 | ≥ 6 months |
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