| 货号 | 10699-1mg |
| 描述 | Adipocyte fatty acid binding protein (A-FABP/aP2) is a carrier protein expressed in both adipocytes and macrophages where it functions in intracellular fatty acid solubilization, trafficking, and metabolism.1 Molecular disruption of A-FABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis.2,3 HTS 01037 is a high-affinity ligand of adipocyte fatty acid binding protein (A-FABP/aP2) (Ki = 0.67 μM) that presumably competes with fatty acids for functional binding in the ligand-binding cavity of A-FABP/aP2.4 At a concentration of 10 μM, HTS 01037 antagonizes the protein-protein interaction of A-FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes. 4 HTS 01037 inhibits lipolysis in 3T3L1 adipocytes and reduces lipopolysaccharide-stimulated inflammation in bone marrow-derived macrophages, both effects of which are similar to the phenotype of A-FABP/aP2 knockout mice.4 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Massolini, G. and Calleri, E. Survey of binding properties of fatty acid-binding proteins chromatographic methods. Journal of Chromatography B 797, 255-268 (2003). 2.Perrella, M.A.,Pellacani, A.,Layne, M.D., et al. Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice. The FASEB Journal 15, 1774-1776 (2001). 3.Furuhashi, M.,Tuncman, G.,Görgün, C.Z., et al. Treatment of diabetes and atherosclerosis by inhibiting fatty-acid-binding protein aP2. Nature 447, 959-965 (2007). 4.Hertzel, A.V.,Hellberg, K.,Reynolds, J.M., et al. Identification and characterization of a small molecule inhibitor of fatty acid binding proteins. Journal of Medicinal Chemistry 52, 6024-6031 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 337.4 |
| 分子式 | C14H11NO5S2 |
| CAS号 | 682741-29-3 |
| 稳定性 | ≥ 2 years |
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