(S)-Equol
货号：
10010173-1mg 基本售价：
224.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010173-1mg |
| 描述 | Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzen by human intestinal microflora.1,2 The estrogen receptor (ER) agonist activity of the naturally occurring (S)-enantiomer (EC50 = 85 and 65 nM for human ERα and ERβ, respectively) is similar to that of genistein but exceeds that of daidzein.2 (S)-Equol preferentially binds ERβ (Ki = 0.73 nM) and demonstrates approximately 9-fold lower affinity for ERα (Ki = 6.41 nM).1 (S)-equol is also a potent antagonist of dihydrotestosterone, which has important implications for prostate cancer and other androgen-mediated pathologies.3 |
| 别名 | 4,7-Dihydroxyisoflavan;(−)-Equol;4,7-Isoflavandiol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Setchell, K.D.R.,Clerici, C.,Lephart, E.D., et al. S-equol, a potent ligand for estrogen receptor ß, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. American Journal of Clinical Nutrition 81, 1072-1079 (2005).
2.Muthyala, R.S.,Ju, Y.H.,Sheng, S., et al. Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorganic & Medicinal Chemistry 12, 1559-1567 (2004).
3.Lund, T.D.,Munson, D.J.,Haldy, M.E., et al. Equol is a novel anti-androgen that inhibits prostate growth and hormone feedback. Biology of Reproduction 70, 1188-1195 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 242.3 |
| 分子式 | C15H14O3 |
| CAS号 | 531-95-3 |
| 稳定性 | ≥ 2 years |
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