Recombinant Mouse Stanniocalcin 2/STC-2 Protein, CF (50 UG)【科瑞奥博】

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Recombinant Mouse Stanniocalcin 2/STC-2 Protein, CF (50 UG)

货号： 9406-SO-050 基本售价： 4451.6 元规格： 50 UG

产品信息

概述
货号	9406-SO-050
别名	Stanniocalcin 2; stanniocalcin-2; STC2; STC-2; STC-2Stanniocalcin-related protein; STC-related protein; STCRP
来源	Mouse myeloma cell line, NS0-derived Thr25-Arg296, with a C-terminal 6-His tag
产品组分

性能
供应商	R&D Systems
Entrez Gene IDs	8614 (Human); 20856 (Mouse)
内毒素水平	<0.10 EU per 1 μg of the protein by the LAL method.
生物活性	Measured by its ability to inhibit Wnt-3a-induced alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. The ED₅₀ for this effect is 75-450 ng/ml in the presence of 10 ng/ml of Recombinant Mouse Wnt‑3a (Catalog # 1324-WN).
溶解方法	Reconstitute at 500 μg/mL in PBS.
背景	MouseSTC-2 (Stanniocalcin-2) is a secreted disulfide-linked homodimericglycoprotein hormone that is related to the STC protein. It is first discoveredfrom corpuscles of stannous, an endocrine gland unique to bony fish (1-3). The272 amino acid (aa) mature mouse STC-2 has an 86% homology with the humanform. STC‑2 has been described as havinga role in human adult height and is involved in the GIANT consortium (4, 5). STC-2 is expressed in a wide variety of tissues. It regulates calcium and phosphate homeostasis (1-3), enhances mesenchymal stem cellsurvival (6), promotes cell proliferation in cervical cancer (7), suppressesbreast cancer cell migration and invasion (8), promotes osteoblastdifferentiation (9), and inhibits longitudinal bone growth directly at thegrowth plate (10). It is also a biomarker for cervical and lung cancers (11, 12).Fform
Accession #	O88452 N-terminal Se
运输条件	Blue Ice
预期分子量	31 kDa
SDS-PAGE	33-44 kDa, reducing conditions
存放说明	-20℃
纯度	>90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
参考文献	Wagner, G.F. et al. (1995) Proc. Natl. Acad. Sci. 92:1871. Zhang, J. et al. (1998) Protein Expression and Purification. 12:390. Takei, Y. et al. (2012) Bone. 50:998. Marouli, E. et al. (2017) Nature 542:186. Holmes, D. (2017) Nature Reviews Endocrinology. 13:190. Kim PH, et al. (2015) BMB Rep. 48:702. Wang Y, et al. (2015) Biochem Biophys Res Commun. 466:362. Hou J, et al. (2015) PLoS One.10:e0122179. Zhou J, et al. (2016) Mol Med Rep. 14:5653. Wu S, et al. (2006) J Biol Chem. 281:5120. Shen XJ, et al. (2014) Int J Clin Exp Pathol. 7: 8770. Na SS, et al. (2015) Biochim Biophys Acta. 1854:668.

参考图片

Recombinant Mouse Stanniocalcin 2/STC-2 (Catalog # 9406-SO) inhibits Recombinant Mouse Wnt-3a induced alkaline phosphatase production by MC3T3-E1 mouse preosteoblast cells. The ED₅₀ for this effect is 75‑450 ng/mL in the presence of 10 ng/mL of Recombinant Mouse Wnt‑3a (Catalog # 1324-WN).