| 货号 | 9397-CM-050 | ||||||
| 别名 | carcinoembryonic antigen-related cell adhesion molecule 19; CEACAM19; CEACAM-19; CEAL1 | 全称 | Carcinoembryonic Antigen-related Cell Adhesion Molecule 19 | ||||
| 来源 | Human embryonic kidney cell, HEK293-derived
| ||||||
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 56971 (Human); 319930 (Mouse); 680640 (Rat) |
| 内毒素水平 | <0.10 EU per 1 μg of the protein by the LAL method. |
| 生物活性 | Measured by the ability of the immobilized protein to support the adhesion of the L Cells mouse fibroblast cell line. The ED50 for this effect is 0.4-2.4 μg/mL |
| 溶解方法 | Reconstitute at 500 μg/mL in PBS. |
| 背景 | Carcinoembryonic antigen-related cell adhesion molecule-19 (CEACAM-19),also known as CEA-like gene 1 (CEAL1), is a member of the CEACAM subfamily ofglycoproteins in the immunoglobulin (Ig) superfamily. Mature humanCEACAM-19 consists of a 125 amino acid (aa) extracellular domain, a21 aa helical transmembrane domain, and a 122 aa cytoplasmic domain (1,2).The extracellular domain contains an Ig-like domain as well as a glycosylationsite, while the cytoplasmic domain is predicted to contain at least oneimmunoreceptor tyrosine-based activation motif (ITAM) (3,4). The extracellulardomain of human CEACAM-19 shows 71%, 72%, and 78% aa identity to mouse,rat, and bovine CEACAM-19. The CEACAMfamily of proteins are involved in numerous intercellular-adhesion andintracellular signaling processes including cell adhesion, cell growth, recognitionand differentiation, angiogenesis, and apoptosis (5,6). CEACAM-19 expressionhas been identified in a wide range of tissues including prostate, uterus,fetal brain, mammary and adrenal glands, skeletal muscle, small intestine, andkidney (1). Human CEACAM-19 has been found to be overexpressed in BT-474, BT20,and T47D breast cancer cell lines as well as LNCaP prostate cancer cells,suggesting a role in tumor progression and metastasis (1,3, 7). Theoverexpression in breast cancer patients is associated with poor prognosis (7). |
| Accession # | Q7Z692-1 N-termina |
| 运输条件 | Blue Ice |
| 预期分子量 | 40 kDa |
| SDS-PAGE | 42-56 kDa, reducing conditions |
| 存放说明 | -20℃ |
| 纯度 | >95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining. |
| 参考文献 |
|
Immobilized Recombinant Human CEACAM-19 (Catalog # 9397-CM)enhances L Cells mouse fibroblasts adhesion. The ED50 for this effect is 0.4-2.4 μg/mL. |
