| 货号 | 9414-AN-050 |
| 别名 | AIV; Annexin A4; annexin IV (placental anticoagulant protein II); Annexin IV; Annexin-4; ANX4; ANX4Carbohydrate-binding protein p33/p41; ANXA4; Chromobindin-4; chromobindin-4,35-beta calcimedin; DKFZp686H02120; Endonexin I; Lipocortin IV; MGC75105; P32.5; PAP-II; PIG28; Placental anticoagulant protein II; PP4-X; proliferation-inducing gene 28; proliferation-inducing protein 28; Protein II; ZAP36 |
| 来源 | E. coli-derived Ala2-Asp321, with a C-terminal 6-His tag |
| 产品组分 |
| 供应商 | R&D Systems |
| Entrez Gene IDs | 307 (Human); 11746 (Mouse); 79124 (Rat) |
| 内毒素水平 | <0.10 EU per 1 μg of the protein by the LAL method. |
| 生物活性 | Bioassay data are not available. |
| 溶解方法 | Reconstitute at 500 μg/mL in PBS. |
| 背景 | Annexin A4 (ANXA4), also known as Lipocortin IV, placental anticoagulant protein II,and zymogen granule membrane-associated protein of 36 kDa (ZAP36), is a memberof the Annexin protein family. Annexins are calcium-dependentphospholipid-binding proteins that are preferentially located on the cytosolicface of the plasma membrane. The Annexins consist of a unique N-terminal domainfollowed by a homologous C-terminal core domain containing thephospholipid-binding sites. The C-terminal domain is comprised of four 60-70 aaannexin repeats which form a tightly packed disc known as the annexin domain.Members of the Annexin family play a role in cytoskeletal interactions,phospholipase inhibition, regulation of cellular growth, and intracellularsignal transduction pathways. (1) Annexin A4 regulates the transcription fromRNA polymerase II promoter (2). The level of Annexin A4 increases incytoplasm during apoptosis (3). Human Annexin A4 shares 92% aa sequence identity with mouse andrat Annexin A4. |
| Accession # | NP_001144 N-termi |
| 运输条件 | Blue Ice |
| 预期分子量 | 37 kDa |
| SDS-PAGE | 35 kDa, reducing conditions |
| 存放说明 | -20℃ |
| 纯度 | >95%, by SDS-PAGE under reducing conditions and visualized by silver stain. |
| 参考文献 |
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R&D Systems proteins are almost always sold with a bioassay to indicate activity. However, we recognize that sometimes proteins might be novel, and their bioactivity may not be well understood. In addition, some researchers may wish to use polypeptides to make antibodies. To facilitate the advancement of new science, we now offer our Innovator Series of proteins. |
