Methylmalonate
货号：
14885-1g 基本售价：
210.0 元 规格：
1 g
产品信息
概述| 货号 | 14885-1g |
| 描述 | Methylmalonate (MMA) is a dicarboxylic acid that can be derived from methylmalonyl-coenzyme A (methylmalonyl-CoA), which is converted to succinyl-CoA in an enzymatic reaction that requires vitamin B12 (Item No. 18425). A deficiency in vitamin B12 prevents the normal conversion of methylmalonyl-CoA to succinyl-CoA, resulting in increased levels of MMA in the plasma and urine.1 Inherited metabolic disorders that prevent the metabolism of methylmalonyl-CoA can also result in elevated MMA levels.1 Excess MMA produces an acidemia that can interfere with normal neurological development.2,3 |
| 别名 | Isosuccinic Acid;Methylmalonic Acid;MMA;NSC 25201; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Walter, J.H. Vitamin B12 deficiency and phenylketonuria. Mol. Genet. Metab. 104 (Suppl), S52-S54 (2011).
2.Morath, M.A.,Okun, J.G.,Müller, I.B., et al. Neurodegeneration and chronic renal failure in methylmalonic aciduria--a pathophysiological approach. J. Inherit. Metab. Dis. 31(1), 35-43 (2008).
3.Wajner, M. and Coelho, J.C. Neurological dysfunction in methylmalonic acidaemia is probably related to the inhibitory effect of methylmalonate on brain energy production. J. Inherit. Metab. Dis. 20(6), 761-768 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 118.1 |
| 分子式 | C4H6O4 |
| CAS号 | 516-05-2 |
| 稳定性 | ≥ 2 years |
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