GPP 78
货号：
13670-500ug 基本售价：
210.0 元 规格：
500 ug
产品信息
概述| 货号 | 13670-500ug |
| 描述 | Nicotinamide phosphoribosyltransferase (Nampt) converts nicotinamide into nicotinamide mononucleotide (NMN), which is subsequently converted to NAD+ by NMN adenyltransferase. Cancer cells commonly have an unusually high rate of NAD+ turnover, suggesting that inhibition of Nampt might selectively target cancer cells. GPP 78 is a potent inhibitor of Nampt (IC50 = 3 nM).1 It induces cell death in the neuroblastoma cell line SH-SY5Y with an IC50 value of 3.8 nM through a process that appears to involve autophagy.2 |
| 别名 | CAY10618;NMPRTase Inhibitor; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Colombano, G.,Travelli, C.,Galli, U., et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. Journal of Medicinal Chemistry 53, 616-623 (2010).
2.Stein, R.L.,Melandri, F. and Dick, L. Kinetic characterization of the chymotryptic activity of the 20S proteasome. Biochemistry 35, 3899-3908 (1996).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 439.6 |
| 分子式 | C27H29N5O |
| CAS号 | 1202580-59-3 |
| 稳定性 | ≥ 1 year |
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