STF-62247
货号：
13084-1mg 基本售价：
210.0 元 规格：
1 mg
产品信息
概述| 货号 | 13084-1mg |
| 描述 | STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC50 = 625 nM).1 It significantly reduces the growth rate of tumors formed from VHL-deficient cells in mice.1,2,3 STF-62247 induces cytotoxicity in VHL-positive RCC cells only at higher concentrations (IC50 = 16 μM).1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Turcotte, S.,Sutphin, P.D., and Giaccia, A.J. Targeting therapy for the loss of von Hippel-Lindau in renal cell carcinoma a novel molecule that induces autophagic cell death. Autophagy 4(7), 944-946 (2008).
2.Turcotte, S.,Chan, D.A.,Sutphin, P.D., et al. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell 14, 90-102 (2008).
3.Chan, D.A., and Giaccia, A.J. Targeting cancer cells by synthetic lethality autophagy and VHL in cancer therapeutics. Cell Cycle 7(19), 2987-2990 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 267.3 |
| 分子式 | C15H13N3S |
| CAS号 | 315702-99-9 |
| 稳定性 | ≥ 2 years |
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