| 货号 | 12092-25mg |
| 描述 | Etoposide is a plant alkaloid which acts as an inhibitor of topoisomerase II (IC50 = 60.3 μM).1,2 Notably, this compound can have much greater potencies when evaluated in cell-based cytotoxicity assays (e.g.,IC50 = 5.14 nM for MCF-7 cells).3 Etoposide inhibits DNA synthesis by forming a ternary complex with DNA and topoisomerase II, inducing breaks in double stranded DNA. Accumulated breaks in DNA prevent entry into mitosis and lead to cell death.3 Recent bioassay data suggest that etoposide can also inhibit nuclear receptor coactivator 3 (IC50 = 2.48 μM), a steroid receptor coactivator with histone acetyltransferase activity.4 Interestingly, histone deacetylase inhibitors can sensitize multidrug-resistant cancer cells to etoposide.5 |
| 别名 | Celltop;EPE;Fytosid;Lastet;NSC 141540;VP-16-123;Zuyeyidal; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Chen, G.L.,Yang, L.,Rowe, T.C., et al. Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. The Journal of Biological Chemisty 259(21), 13560-13566 (1984). 2.Wu, W.B.,Ou, J.B.,Huang, Z.H., et al. Synthesis and evaluation of mansonone F derivatives as topoisomerase inhibitors. European Journal of Medicinal Chemistry 46(8), 3339-3347 (2011). 3.Drevs, J.,Fakler, J.,Eisele, S., et al. Antiangiogenic potency of various chemotherapeutic drugs for metronomic chemotherapy. Anticancer Research 24, 1759-1764 (2004). 4.OMalley, B. Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 3 (SRC;NCOA3) - BioAssay summary. . 5.Hajji, N.,Wallenborg, K.,Vlachos, P., et al. Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the senstitivity to the topoisomerase II inhibitor etoposide. Oncogene 29, 2192-2204 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 588.6 |
| 分子式 | C29H32O13 |
| CAS号 | 33419-42-0 |
| 稳定性 | ≥ 2 years |
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