Andrographolide
货号：
11679-50mg 基本售价：
210.0 元 规格：
50 mg
产品信息
概述| 货号 | 11679-50mg |
| 描述 | Andrographolide is a labdane diterpenoid that is the main bioactive component of A. paniculata, a well-recognized medicinal plant in Asia. It exerts a wide range of therapeutic actions, including immunosuppressant, antithrombotic, anti-inflammatory, antineoplastic, antiviral, antibacterial, antidiabetic, antioxidative stress, antipyretic, antioedematogenic, and antinociceptive activities.1 Andrographolide treatment inhibits nuclear factor kappa B (NF-κB) binding to DNA promoters of target genes (IC50 = ~15 μM), by forming a covalent adduct with reduced cysteine (62) of the NF-κB p50 subunit, and can also induce expression of the CYP1A subfamily of the cytochrome P450 family of enzymes.2,3 At 5 μg/g body weight it can suppress the activation of NF-κB in stimulated endothelial cells, reducing the expression of the cell adhesion molecule E-selectin, abrogating the cytokine- and endotoxin-induced peritoneal infiltration of neutrophils, attenuating septic shock, and preventing allergic lung inflammation in a mouse model of asthma.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jarukamjorn, K., and Nemoto, N. Pharmacological aspects of Andrographis paniculata on health and its major diterpenoid constituent andrographolide. J.Health Sci. 54(4), 370-381 (2008).
2.Varma, A.,Padh, H., and Shrivastava, N. Andrographolide: A new plant-derived antineoplastic entity on horizon. Evidence-Based Complementary and alternative Medicine 2011, 1-9 (2011).
3.Xia, Y.F.,Ye, B.Q.,Li, Y.D., et al. Andrographolide attenuates inflammation by inhibition of NF-κB activation through covalent modification of reduced cysteine 62 of p50. Journal of Immunology 173(6), 4207-4217 (2004).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 350.5 |
| 分子式 | C20H30O5 |
| CAS号 | 5508-58-7 |
| 稳定性 | ≥ 2 years |
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