| 货号 | 11164-50mg |
| 描述 | 5-Azacytidine, a chemical analogue of the DNA and RNA nucleoside cytidine, is an inhibitor of DNA methyltransferases, potentially serving to reverse epigenetic changes.1 It reduces hypermethylation associated with certain diseases, including myelodysplastic syndromes (IC50s = 2.4 and 2.6 μM for in vitro anti-myeloma activity) and cancer (IC50s ~ 0.4 μM for inhibiting proliferation of various cancer cell lines).2,3,4 5-Azacytidine has a reported half-life of 17 hours and is considerably cytotoxic; it must be incorporated into DNA to covalently trap DNA methyltransferases.1 |
| 别名 | Antibiotic U 18496;5-AzaC;Ladakamycin;Mylosar;NSC 102816;NSC 103-627;U 18496;WR 183027; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Brueckner, B.,Boy, R.G.,Siedlecki, P., et al. Epigenetic reactivation of tumor suppressor genes by a novel small-molecule inhibitor of human DNA methyltransferases. Cancer Research 65(14), 6305-6311 (2005). 2.Esteller, M. Epigenetics in cancer. N. Engl. J. Med. 358, 1148-1159 (2008). 3.Lyko, F. and Brown, R. DNA methyltransferase inhibitors and the development of epigenetic cancer therapies. J. Natl. Cancer Inst. 97(20), 1498-1506 (2005). 4.Stresemann, C.,Brueckner, B.,Musch, T., et al. Functional diversity of DNA methyltransferase inhibitors in human cancer cell lines. Cancer Res. 66(5), 2794-2800 (2006). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 244.2 |
| 分子式 | C8H12N4O5 |
| CAS号 | 320-67-2 |
| 稳定性 | ≥ 2 years |
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