PIT-1
货号：
10728-5mg 基本售价：
210.0 元 规格：
5 mg
产品信息
概述| 货号 | 10728-5mg |
| 描述 | PtdIns-(3,4,5)-P3(PIP3) serves as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains such as phosphatidylinositol 3-kinase (PI3K) or PTEN. Protein binding to PIP3 is important for cytoskeletal rearrangement and membrane trafficking and initiates an intricate signaling cascade that has been implicated in cancer.1 PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM.2 PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM).2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vivanco, I. and Sawyers, C.L. The phosphatidylinositol 3-kinase-AKT pathway in human cancer. Nature Reviews.Cancer 2, 489-501 (2002).
2.Miao, B.,Skidan, I.,Yang, J., et al. Small molecule inhibition of phosphatidylinositol-3,4,5-triphosphate (PIP3) binding to pleckstrin homology domains. Proceedings of the National Academy of Sciences of the United States of America 107(46), 20126-20131 (2010).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351.8 |
| 分子式 | C14H10ClN3O4S |
| CAS号 | 53501-41-0 |
| 稳定性 | ≥ 2 years |
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