JNJ-7777120
货号：
10011925-1mg 基本售价：
210.0 元 规格：
1 mg
产品信息
概述| 货号 | 10011925-1mg |
| 描述 | JNJ-7777120 is a potent and selective histamine H4 receptor antagonist, with a Ki value of approximately 4 nM against the human, mouse, and rat H4 receptors.1 Its Ki values for the histamine H1-3 receptors exceed 1 μM, regardless of species, and it has no or negligible effects on a range of other receptors and transporters.1 JNJ-777120 inhibits mast cell chemotaxis induced by 10 μM histamine (IC50 = 40 nM) and reduces neutrophil influx in mouse peritonitis models (10 mg/kg s.c.).1 It also impairs eosinophil and lymphocyte influx into airways during allergic airway inflammation.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Thurmond, R.L.,Desai, P.J.,Dunford, P.J., et al. A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. Journal of Pharmacology and Experimental Therapeutics 309(1), 404-413 (2004).
2.Dunford, P.J.,ODonnell, N.,Riley, J.P., et al. The histamine H4 receptor mediates allergic airway inflammation by regulating the activation of CD4+ T cells. Journal of Immunology 176, 7062-7070 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 277.8 |
| 分子式 | C14H16ClN3O |
| CAS号 | 459168-41-3 |
| 稳定性 | ≥ 2 years |
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