| 货号 | 10011561-1mg |
| 描述 | The prostaglandin E2(PGE2) receptor EP1 is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51089 is a selective EP1 antagonist, first shown to have in vivo analgesic activity in mice (ED50 = 6.3 mg/kg when given subcutaneously) and in the rat.1,2 SC-51089 also inhibits the growth of glioma cell lines in vitro(IC50 = ~1 μM) and slows tumor growth in vivo.3 In addition, SC-51089 is neuroprotective, attenuating neuronal cell death in response to oxidative stress, an effect that is also found in EP1-/- mice and mediated by PGE2.4,5 |
| 别名 | CID132748; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Hallinan, E.A.,Hagen, T.J.,Husa, R.K., et al. N-substituted dibenzoxazepines as analgesic PGE2 antagonists. Journal of Medicinal Chemistry 36, 3293-3299 (1993). 2.Malmberg, A.B.,Rafferty, M.F. and Yaksh, T.L. Antinociceptive effect of spinally delivered prostaglandin E receptor antagonists in the formalin test on the rat. Neuroscience Letters 173, 193-196 (1994). 3.Matsuo, M.,Yoshida, N.,Zaitsu, M., et al. Inhibition of human glioma cell growth by a PHS-2 inhibitor, NS398, and a prostaglandin E receptor subtype EP1-selective antagonist, SC51089. Journal of Neuro-Oncology 66, 285-292 (2004). 4.Carrasco, E.,Casper, D. and Werner, P. PGE2 receptor EP1 renders dopaminergic neurons selectively vulnerable to low-level oxidative stress and direct PGE2 neurotoxicity. Journal of Neuroscience Research 85, 3109-3117 (2007). 5.Saleem, S.,Li, R.c.,Wei, G., et al. Effects of EP1 receptor on cerebral blood flow in the middle cerebral artery occlusion model of stroke in mice. Journal of Neuroscience Research 85(11), 2433-2440 (2007). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 459.3 |
| 分子式 | C22H19ClN4O3 ?HCl |
| CAS号 | 146033-02-5 |
| 稳定性 | ≥ 2 years |
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