SC-51322
货号：
10010744-1mg 基本售价：
210.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010744-1mg |
| 描述 | The prostaglandin E2(PGE2) receptor (EP1) is involved in triggering PGE2-mediated pain as well as neuronal survival and growth. SC-51322 is a selective EP1 antagonist that inhibits PGE2 signaling in a guinea pig ileum muscle strip assay with a pA2 value of 8.1 and demonstrates analgesic activity in a mouse writhing assay with an ED50 value of 0.9 mg/kg.1 It is pharmacologically similar to SC-51089, but does not release hydrazine, a known carcinogen to rats, as does SC-51089.1 SC-51322 potentiates the vasorelaxation of human pulmonary vein induced by PGE2 with an EC50 value of 7.75 µM.2 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Hallinan, E.A.,Hagen, T.J.,Tsymbalov, S., et al. Aminoacetyl moiety as a potential surrogate for diacylhydrazine group of SC-51089, a potent PGE2 antagonist, and its analogs. Journal of Medicinal Chemistry 39, 609-613 (1996).
2.Foudi, N.,Kotelevets, L.,Louedec, L., et al. Vasorelaxation induced by prostaglandin E2 in human pulmonary vein: Role of the EP4 receptor subtype. British Journal of Pharmacology 154, 1631-1639 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 457.9 |
| 分子式 | C22H20ClN3O4S |
| CAS号 | 146032-79-3 |
| 稳定性 | ≥ 2 years |
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