6,7-dihydroxy Bergamottin
货号：
10009598-1mg 基本售价：
210.0 元 规格：
1 mg
产品信息
概述| 货号 | 10009598-1mg |
| 描述 | 6,7-dihydroxy Bergamottin (6,7-DHB) is a potent inhibitor of CYP3A4 (IC50 = 25 µM).1 It appears to be the primary compound in grapefruit juice that is responsible for inhibition of testosterone 6β-hydrolase activity. Ingestion of grapefruit juice during treatment regimes with drugs normally metabolized by cytochrome P450 enzymes of the CYP3A subfamily results in a substantial increase in plasma concentration of these agents.2,1 However, giving a patient grapefruit juice or just 6,7-DHB could be advantageous in cases where a drug is metabolized too quickly by CYP3A4. |
| 别名 | 6,7-DHB; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Edwards, D.J.,Bellevue, F.H., III, and Woster, P.M. Identification of 6,7-dihydroxybergamottin, a cytochrome P450 inhibitor, in grapefruit juice. Drug Metabolism and Disposition 24(12), 1287-1290 (1996).
2.Bellevue, F.H., III,Woster, P.M.,Edwards, D.J., et al. Synthesis and biological evalution of 6,7-dihydroxybergamottin (6,7-DHB), a naturally occurring inhibitor of cytochrome P450 3A4. Bioorganic & Medicinal Chemistry Letters 7(20), 2593-2598 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 372.4 |
| 分子式 | C21H24O6 |
| CAS号 | 145414-76-2 |
| 稳定性 | ≥ 2 years |
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