Ketorolac
货号：
9001148-100mg 基本售价：
196.0 元 规格：
100 mg
产品信息
概述| 货号 | 9001148-100mg |
| 描述 | Ketorolac is a non-steroidal anti-inflammatory drug (NSAID) that belongs to the class of heteroaryl acetic acid derivatives. It is a non-selective cyclooxygenase (COX) inhibitor, being marketed as an analgesic to manage postoperative pain as well as an ophthalmic solution to treat ocular pain and inflammation.1 Ketorolac potently inhibits COX-1 and COX-2 (IC50s = 20 nM) in vivo. In a mouse model of acute pain, ketorolac 30 mg/kg suppressed both pain and peripheral PGE2levels.2 As typical of many NSAIDs, ketorolac is a racemic mixture. (S)-Ketorolac exhibits potent COX1 and COX2 (IC50s = 0.1 and 2.7 μM) inhibition, whereas (R)-ketorolac is >100-fold less active on both COX subtypes.3 |
| 别名 | Acular LS®;Acular PF®;RS 37619;Sprix®; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gordon, S.M.,Brahim, J.S.,Rowan, J., et al. Pharmacodynamics and drug action. Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: Replicate clinical trials in a tissue injury model. Clin. Pharmacol. Ther. 72(2), 175-183 (2002).
2.Zhang, Y.,Shaffer, A.,Portanova, J., et al. Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production. Journal of Pharmacology and Experimental Therapeutics 283, 1069-1075 (1997).
3.Handley, D.A.,Cervoni, P.,McCray, J.E., et al. Preclinical enantioselective pharmacology of (R)- and (S)- ketorolac. J. Clin. Pharmacol. 38, 25S-35S (1998).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 22 |
| 纯度 | ≥95% |
| 计算分子量 | 255.3 |
| 分子式 | C15H13NO3 |
| CAS号 | 74103-06-3 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
