| 货号 | 9000059-1g |
| 描述 | The jasmonates are a group of plant stress hormones that naturally occur in plants following exposure to certain types of stresses, including pathogen and herbivore attacks. (±)-Jasmonic acid methyl ester is a mixture of trans (3R/7R and 3S/7S) isomers. (±)-Jasmonic acid methyl ester induces the synthesis of proteinase inhibitors in plant leaves.1 In cancer cells, it suppresses proliferation and induces apoptosis.2 More specifically, methyl jasmonate inhibits hexokinase that is bound to mitochondria.3 As hexokinase is overexpressed in cancer cells and contributes to cancer cell growth and survival, methyl jasmonate’s disruption of mitochondrial hexokinase activity selectively targets, and kills, cancer cells. (±)-Jasmonic acid methyl ester derivatives also have potential as anti-inflammatory agents.4 |
| 别名 | (±)-Methyl Jasmonate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Farmer, E.E. and Ryan, C.A. Interplant communication: Airborne methyl jasmonate induces synthesis of proteinase inhibitors in plant leaves. Proceedings of the National Academy of Sciences of the United States of America 87, 7713-7716 (1990). 2.Fingrut, O. and Flescher, E. Plant stress hormones suppress the proliferation and induce apoptosis in human cancer cells. Leukemia 16, 608-616 (2002). 3.Goldin, N.,Arzoine, L.,Heyfets, A., et al. Methyl jasmonate binds to and detaches mitochondria-bound hexokinase. Oncogene 27, 4636-4643 (2008). 4.Dang, H.T.,Lee, H.J.,Yoo, E.S., et al. New jasmonate analogues as potential anti-inflammatory agents. Bioorganic & Medicinal Chemistry 16, 10228-10235 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% (mixture of isomers) |
| 计算分子量 | 224.3 |
| 分子式 | C13H20O3 |
| CAS号 | 39924-52-2 |
| 稳定性 | ≥ 1 year |
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