DMOG
货号：
71210-10mg 基本售价：
196.0 元 规格：
10 mg
产品信息
概述| 货号 | 71210-10mg |
| 描述 | The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-1α prolyl hydroxylase (HIF-PH).1 DMOG is a cell permeable, competitive inhibitor of HIF-PH. It acts to stabilize HIF-1α expression at normal oxygen tensions in cultured cells, at concentrations between 0.1 and 1 mM.1 DMOG is therefore expected to act as a pro-angiogenic compound, acting via the HIF-1α system.2,3 |
| 别名 | Dimethyloxallyl Glycine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Jaakkola, P.,Mole, D.R.,Tian, Y.M., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472 (2001).
2.Bruick, R. and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340 (2001).
3.Ivan, M.,Kondo, K.,Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464-468 (2001).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 175.1 |
| 分子式 | C6H9NO5 |
| CAS号 | 89464-63-1 |
| 稳定性 | ≥ 1 year |
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