| 货号 | 71200-10mg |
| 描述 | The pro-angiogenic factor HIF-1α is targeted for destruction in normoxic environments by the hydroxylation of a specific proline residue, P564, by the oxygen-sensing enzyme HIF-α prolyl hydroxylase (HIF-PH).1 2,4-DPD is a cell permeable, competitive inhibitor of HIF-PH. 2,4-DPD inhibits the hydroxylation of P564 by acting as a competitive inhibitor of the HIF-PH cofactor α-keto glutarate, with effective concentrations in the low µM range.2 2,4-DPD is therefore expected to act as a pro-angiogenic compound, via the HIF-1α system.3,4 |
| 别名 | 2,4-Diethylpyridine dicarboxylate; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Jaakkola, P.,Mole, D.R.,Tian, Y.M., et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468-472 (2001). 2.Friedman, L.,Higgin, J.J.,Moulder, G., et al. Prolyl 4-hydroxylase is required for viability and morphogenesis in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America 97, 4736-4741 (2000). 3.Bruick, R. and McKnight, S.L. A conserved family of prolyl-4-hydroxylases that modify HIF. Science 294, 1337-1340 (2001). 4.Ivan, M.,Kondo, K.,Yang, H., et al. HIFα targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464-468 (2001). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 223.2 |
| 分子式 | C11H13NO4 |
| CAS号 | 41438-38-4 |
| 稳定性 | ≥ 1 year |
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