SC-560
货号：
70340-1mg 基本售价：
196.0 元 规格：
1 mg
产品信息
概述| 货号 | 70340-1mg |
| 描述 | SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex™) and rofecoxib (Vioxx™). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 µM.1 Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process.2 In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor.3 The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Smith, C.J.,Zhang, Y.,Koboldt, C.M., et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proceedings of the National Academy of Sciences of the United States of America 95, 13313-13318 (1998).
2.Masferrer, J.L.,Zweifel, B.S.,Manning, P.T., et al. Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. Proceedings of the National Academy of Sciences of the United States of America 91, 3228-3232 (1994).
3.Brenneis, C.,Maier, T.J.,Schmidt, R., et al. Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition. The FASEB Journal 20, 1352-1360 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 352.7 |
| 分子式 | C17H12ClF3N2O |
| CAS号 | 188817-13-2 |
| 稳定性 | ≥ 2 years |
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