PRIMA-1
货号：
63520-1mg 基本售价：
196.0 元 规格：
1 mg
产品信息
概述| 货号 | 63520-1mg |
| 描述 | Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.1 It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Bykov, V.J.N.,Issaeva, N.,Shilov, A., et al. Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound. Nature Medicine 8(3), 282-288 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 185.2 |
| 分子式 | C9H15NO3 |
| CAS号 | 5608-24-2 |
| 稳定性 | ≥ 1 year |
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