| 货号 | 14050-1mg |
| 描述 | AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1receptors.1 AH 6809 blocks the PGE2-induced accumulation of cAMP in COS cells transfected with the human EP2receptor.2 It also blocks the accumulation of Ca2+inXenopus oocytes expressing the human EP1receptor.3 In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent.4 In the mouse, AH 6809 has the highest affinity for the EP2 receptor, but also acts as a weak ligand at the murine EP1 and DP1receptors.5 In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD2, but not PGI2, with an EC50 of about 5 x 10−5M.6 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Abramovitz, M.,Adam, M.,Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et Biophysica Acta 1483, 285-293 (2000). 2.Woodward, D.F.,Pepperl, D.J.,Burkey, T.H., et al. 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochemical Pharmacology 50, 1731-1733 (1995). 3.Funk, C.D.,Furci, L.,Fitzgerald, G.A., et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. The Journal of Biological Chemisty 268, 26767-26772 (1993). 4.Coleman, R.A.,Kennedy, I. and Sheldrick, R.L.G. AH6809, a prostanoid EP1 receptor blocking drug. British Journal of Pharmacology 85, 273P (1985). 5.Kiriyama, M.,Ushikubi, F.,Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. British Journal of Pharmacology 122, 217-224 (1997). 6.Keery, R.J. and Lumley, P. AH6809, a prostaglandin DP-receptor blocking drug on human platelets. British Journal of Pharmacology 94, 745-754 (1988). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | 4 |
| 纯度 | ≥98% |
| 计算分子量 | 298.3 |
| 分子式 | C17H14O5 |
| CAS号 | 33458-93-4 |
| 稳定性 | ≥ 2 years |
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