| 货号 | 13662-100mg |
| 描述 | Arecoline is a natural alkaloid that is found in the betel nut of the Areca palm. It is an agonist of the muscarinic acetylcholine receptors with EC50 values of 7, 95, 11, 410, and 69 nM for M1, M2, M3, M4, and M5, respectively.1,2,3 Generally, arecoline causes smooth muscle contraction.1,4,5 Arecoline and other muscarinic receptor agonists have been shown to improve learning and memory and may prove to be useful in treating dementia.6,7,8 |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Okamoto, H.,Prestwich, S.A.,Asai, S., et al. Muscarinic agonist potencies at three different effector systems linked to the M2 or M3 receptor in longitudinal smooth muscle of guinea-pig small intestine. British Journal of Pharmacology 135, 1765-1775 (2002). 2.Thomas, R.L.,Langmead, C.J.,Wood, M.D., et al. Contrasting effects of allosteric and orthosteric agonists on M1 muscarinic acetylcholine receptor internalization and down-regulation. Journal of Pharmacology and Experimental Therapeutics 331(3), 1086-1095 (2009). 3.Heinrich, J.N.,Butera, J.A.,Carrick, T., et al. Pharmacological comparison of muscarinic ligands: Historical versus more recent muscarinic M1-preferring receptor agonists. European Journal of Pharmacology 605, 53-56 (2009). 4.Garssen, J.,Van Loveren, H.,Gierveld, C.M., et al. Functional characterization of muscarinic receptors in murine airways. British Journal of Pharmacology 109, 53-60 (1993). 5.Ikeda, Y. and Kanai, A. Urotheliogenic modulation of intrinsic activity in spinal cord-transected rat bladders: Role of mucosal muscarinic receptors. American Journal of Physiology.Renal Physiology 295, F454-F461 (2008). 6.Bratt, A.M.,Kelly, M.E.,Domeney, A.M., et al. Acute and chronic arecoline: Effects on a scopolamine-induced deficit in complex maze learning. Pharmacology, Biochemistry, and Behavior 53(3), 713-721 (1996). 7.Morley, J.E.,Farr, S.A. and Flood, J.F. Antibody to amyloid β protein alleviates impaired acquisition, retention, and memory processing in SAMP8 mice. Neurobiology of Learning and Memory 78, 125-138 (2002). 8.Christie, J.E.,Shering, A.,Ferguson, J., et al. Physostigmine and arecoline: Effects of intravenous infusions in Alzheimer presenile dementia. British Journal of Psychiatry 138, 46-50 (1981). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 236.1 |
| 分子式 | C8H13NO2 • HBr |
| CAS号 | 300-08-3 |
| 稳定性 | ≥ 2 years |
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