WZ811
货号：
13639-1mg 基本售价：
196.0 元 规格：
1 mg
产品信息
概述| 货号 | 13639-1mg |
| 描述 | The CXC chemokine receptor-4 (CXCR4) is a G protein-coupled receptor that is specific for stromal cell-derived factor-1 (SDF-1/ CXCL12). Activation of CXCR4 promotes homing of hematopoietic stem cells, chemotaxis and quiescence of lymphocytes, and growth and metastasis of certain cancer cell types. Moreover, CXCR4 on CD4+ T-cells is used by CXCR4-selective HIV forms as a gateway for T-cell infection. WZ811 is a potent inhibitor of binding of an SDF-1 peptide mimic to CXCR4 (EC50 = 0.3 nM).1 It prevents SDF-1/CXCL12-mediated modulation of cAMP (EC50 = 1.2 nM) in cells and blocks SDF-1-induced Matrigel™ invasion by MDA-MB-231 human breast adenocarcinoma cells (EC50 = 5.2 nM).1 The effectiveness of WZ811 in animals remains to be elucidated. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Zhan, W.,Liang, Z.,Zhu, A., et al. Discovery of small molecule CXCR4 antagonists. Journal of Medicinal Chemistry 50, 5655-5664 (2007).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 290.4 |
| 分子式 | C18H18N4 |
| CAS号 | 55778-02-4 |
| 稳定性 | ≥ 2 years |
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