PPM-18
货号：
13327-1mg 基本售价：
196.0 元 规格：
1 mg
产品信息
概述| 货号 | 13327-1mg |
| 描述 | PPM-18 is a naphthoquinone compound that inhibits NF-κB activation in vitroandin vivo(IC50 = 5 µM).1,2 Through this action, it inhibits the expression of inducible nitric oxide synthase (iNOS) in macrophages treated with lipopolysaccharide and suppresses inflammation and sepsis.1 |
| 别名 | NSC 73233; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Yu, S.M.,Wu, J.F.,Lin, T.L., et al. Inhibition of nitric oxide synthase expression by PPM-18, a novel anti-inflammatory agent, in vitro and in vivo. Biochemistry Journal 328, 363-369 (1997).
2.Davis, M.E.,Grumbach, I.M.,Fukai, T., et al. Shear stress regulates endothelial nitric-oxide synthase promoter activity through nuclear factor κB binding. The Journal of Biological Chemisty 279(1), 163-168 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 277.3 |
| 分子式 | C17H11NO3 |
| CAS号 | 65240-86-0 |
| 稳定性 | ≥ 2 years |
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