Farnesyl Thiosalicylic Acid Amide
货号：
13175-1mg 基本售价：
196.0 元 规格：
1 mg
产品信息
概述| 货号 | 13175-1mg |
| 描述 | Association of Ras protein with the inner surface of the plasma membrane is required for Ras signaling activity. Farnesyl thiosalicylic acid (FTS) amide is an FTS derivative with an amide added to the carboxyl group. FTS amide inhibits the growth of PANC-1 and U87 tumor cells with IC50 values of 20 and 10 µM, respectively, a relatively higher potency compared to that of FTS (IC50s = 35 and 50 µM, respectively).1 Treatment of nude mice bearing either U87 glioblastoma or PANC-1 tumors with 100 mg/kg FTS amide twice daily for four days inhibits tumor growth by at least 50% of controls. |
| 别名 | FTS Amide;Salirasib Amide; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Goldberg, L.,Haklai, R.,Bauer, V., et al. New derivatives of farnesylthiosalicylic acid (salirasib) for cancer treatment: Farnesylthiosalicylamide inhibits tumor growth in nude mice models. Journal of Medicinal Chemistry 52, 197-205 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥96% |
| 计算分子量 | 357.6 |
| 分子式 | C22H31NOS |
| CAS号 | 1092521-74-8 |
| 稳定性 | ≥ 1 year |
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