| 货号 | 10569-100mg |
| 描述 | Ellagic acid is a polyphenolic antioxidant that is abundant in many fruits, vegetables, plant bark, and peels. It has anti-carcinogenic, anti-mutagenic, anti-inflammatory, and organ-preserving properties, presumably related to its ability to alter cytochrome P450 activity and improve metabolism and clearance of xenobiotics, as well as alter immune function.1,2,3 Ellagic acid also blocks methylation of arginine 17 of histone 3 (H3R17) by coactivator-associated arginine methyltransferase 1 (CARM1) without significantly altering histone acetylase or DNA methyltransferase activity.4,5,6 |
| 别名 | Gallogen;Lagistase;TBBD; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Allen, C.T.,Peden-Adams, M.M.,EuDaly, J., et al. Subchronic exposure to ellagic acid impairs cytotoxic T-cell function and suppresses humoral immunity in mice. Immunopharmacol.Immunotoxicol. 25(3), 409-422 (2003). 2.Heber, D. Multitargeted therapy of cancer by ellagitannins. Cancer Letters 269, 262-268 (2008). 3.Girish, C., and Pradhan, S.C. Drug development for liver diseases: Focus on picroliv, ellagic acid and curcumin. Fundamental Clinical Pharmacology 22, 623-632 (2008). 4.Selvi, B.R.,Batta, K.,Kishore, A.H., et al. Identification of a novel inhibitor of coactivator-associated arginine methyltransferase 1 (CARM1)-mediated methylation of histone H3 Arg-17. The Journal of Biological Chemisty 285(10), 7143-7152 (2010). 5.Paluszczak, J.,Krajka-Kuzniak, V., and Baer-Dubowska, W. The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicology Letters 192(2), 119-125 (2010). 6.Lea, M.A.,Ibeh, C.,Han, L., et al. Inhibition of growth and induction of differentiation markers by polyphenolic molecules and histone deacetylase inhibitors in colon cancer cells. Anticancer Research 30(2), 311-318 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 302.2 |
| 分子式 | C14H6O8 |
| CAS号 | 476-66-4 |
| 稳定性 | ≥ 2 years |
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