FR122047 (hydrate)
货号：
10039-1mg 基本售价：
196.0 元 规格：
1 mg
产品信息
概述| 货号 | 10039-1mg |
| 描述 | FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 µM, respectively.1 In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin.2 Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Ochi, T.,Motoyama, Y., and Goto, T. The analgesic effect profile of FR122047, a selective cyclooxygenase-1 inhibitor, in chemical nociceptive models. European Journal of Pharmacology 391, 49-54 (2000).
2.Dohi, M.,Sakata, Y.,Seki, J., et al. The anti-platelet actions of FR122047, a novel cyclooxygenase inhibitor. European Journal of Pharmacology 243, 179-184 (1993).
3.Ochi, T., and Goto, T. Differential effect of FR122047, a selective cyclo-oxygenase-1 inhibitor, in rat chronic models of arthritis. British Journal of Pharmacology 135, 782-788 (2002).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 478 |
| 分子式 | C23H25N3O3S • HCl [H2O] |
| 稳定性 | ≥ 1 year |
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