PIK-90
货号：
10010749-1mg 基本售价：
196.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010749-1mg |
| 描述 | PIK-90 is a potent and cell permeable phosphoinositide 3-kinase (PI3K) inhibitor (IC50 = 11, 350, 18, and 58 nM for p110 subunit isoforms α, β, γ, and δ, respectively).1 Through this action, PIK-90 reduces chemotaxis and induces apoptosis in chronic lymphocytic leukemia B cells.1 It also blocks proliferation of glioma cells in vitro.2 By inhibiting P110α, PIK-90 blocks insulin-stimulated phosphorylation of Akt in L1 adipocytes and L6 myotubes, preventing activation of the mTORC1 pathway.3 |
| 别名 | PIK-85; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Niedermeier, M.,Hennessy, B.T.,Knight, Z.A., et al. Isoform-selective phosphoinositide 3-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: A novel therapeutic approach. Blood 113(22), 5549-5557 (2009).
2.Fan, Q.W.,Knight, Z.A.,Goldenberg, D.D., et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 9, 341-349 (2006).
3.Knight, Z.A.,Gonzalez, B.,Feldman, M.E., et al. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 125, 733-747 (2006).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 351.4 |
| 分子式 | C18H17N5O3 |
| CAS号 | 677338-12-4 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
