| 货号 | 10008282-10mg |
| 描述 | The cysteinyl leukotrienes (CysLTs), LTC4 and LTD4, are potent mediators of asthma and hypersensitivity. They induce bronchoconstriction, increase microvascular permeability, and are vasoconstrictors of coronary arteries. Their biological effects are transduced by a pair of G protein-coupled receptors, CysLT1 and CysLT2.1,2,3 Zafirlukast is a potent, selective CysLT1 receptor antagonist sold under the trade name Accolate for the treatment of asthma as well as for the symptoms associated with allergic rhinitis.4,5,6 It binds to the human CysLT1 and CysLT2 receptors with IC50 values of approximately 5 and 7,400 nM, respectively.1,2,3 |
| 别名 | Accolate™; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lynch, K.R.,ONeill, G.P.,Liu, Q., et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 399, 789-793 (1999). 2.Heise, C.E.,ODowd, B.F.,Figueroa, D.J., et al. Characterization of the human cysteinyl leukotriene 2 receptor. J. Biol. Chem. 275, 30531-30536 (2000). 3.Sarau, H.M.,Ames, R.S.,Chambers, J., et al. Identification, molecular cloning, expression, and characterization of a cysteinyl leukotriene receptor. Mol. Pharmacol. 56, 657-663 (1999). 4.Matassa, V.G.,Maduskuie, T.P., Jr.,Shapiro, H.S., et al. Evolution of a series of peptidoleukotriene antagonists: Synthesis and structure/activity relationships of 1,3,5-substituted indoles and indazoles. Journal of Medicinal Chemistry 33, 1781-1790 (1990). 5.Silverman, R.A.,Nowak, R.M.,Korenblat, P.E., et al. Zafirlukast treatment for acute asthma. Evaluation in a randomized, double-blind, multicenter trail. Chest 126, 1480-1489 (2004). 6.Peters-Golden, M., and Henderson, W.R. The role of leukotrienes in allergic rhinitis. Ann. Allergy Asthma Immunol. 94(6), 609-618 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥97% |
| 计算分子量 | 575.7 |
| 分子式 | C31H33N3O6S |
| CAS号 | 107753-78-6 |
| 稳定性 | ≥ 2 years |
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