YC-1
货号：
81560-1mg 基本售价：
182.0 元 规格：
1 mg
产品信息
概述| 货号 | 81560-1mg |
| 描述 | YC-1 is an nitric oxide (NO)-independent activator of soluble guanylyl cyclase. It inhibits collagen (10 µg/ml) and thrombin (0.1 U/ml) induced platelet aggregation with IC50 values of 11.7-14.6 and 57.3-59.3 µM, respectively.1,2 In the absence of NO or carbon monoxide (CO), 200 µM YC-1 increases the activity of purified soluble guanylyl cyclase 12-fold, with an ED50 value of 20 µM.3 At a concentration of 200 µM, YC-1 potentiates the maximal activity of soluble guanylyl cyclase in the presence of NO or CO by 40% and >3,000%, respectively. |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wu, C.C.,Ko, F.N.,Kuo, S.C., et al. YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase. British Journal of Pharmacology 116, 1973-1978 (1995).
2.Ko, F.N.,Wu, C.C.,Kuo, S.C., et al. YC-1, a novel activator of platelet guanylate cyclase. Blood 84, 4226-4233 (1994).
3.Friebe, A.,Schultz, G., and Koesling, D. Sensitizing soluble guanylyl cyclase to become a highly CO-sensitive enzyme. EMBO Journal 15, 6863-6868 (1996).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥99% |
| 计算分子量 | 304.3 |
| 分子式 | C19H16N2O2 |
| CAS号 | 170632-47-0 |
| 稳定性 | ≥ 2 years |
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