N-(3-pyridyl)-Indomethacin amide
货号：
70274-1mg 基本售价：
182.0 元 规格：
1 mg
产品信息
概述| 货号 | 70274-1mg |
| 描述 | N-(3-pyridyl)-indomethacin amide (N-3PyIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.1 N-3PyIA selectively inhibits human recombinant COX-2 with an IC50 of 0.052 µM. It is about 1,300 times less potent as an inhibitor of ovine recombinant COX-1.1 However, N-3PyIA is not selective as an inhibitor of ovine seminal vesicular COX-1 and ovine placental COX-2. The IC50 values for ovine COX-1 and -2 are 75 and 50 µM, respectively.2 |
| 别名 | N-3PyIA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kalgutkar, A.S.,Marnett, A.B.,Crews, B.C., et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry 43, 2860-2870 (2000).
2.Johnson, J.L. . (1999).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 433.9 |
| 分子式 | C24H20ClN3O3 |
| CAS号 | 261766-29-4 |
| 稳定性 | ≥ 1 year |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
