N-(2-phenylethyl)-Indomethacin amide
货号：
70272-1mg 基本售价：
182.0 元 规格：
1 mg
产品信息
概述| 货号 | 70272-1mg |
| 描述 | N-(2-phenylethyl)-indomethacin amide (N-2PIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2.1 N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 µM, respectively.1,2 It is over 400 times less potent as an inhibitor of human recombinant and ovine COX-1. N-2PIA shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.1 |
| 别名 | N-2PIA; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kalgutkar, A.S.,Marnett, A.B.,Crews, B.C., et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. Journal of Medicinal Chemistry 43, 2860-2870 (2000).
2.Johnson, J.L. . (1999).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 461 |
| 分子式 | C27H25ClN2O3 |
| CAS号 | 261766-32-9 |
| 稳定性 | ≥ 1 year |
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