Salinomycin (sodium salt)
货号：
13579-5mg 基本售价：
182.0 元 规格：
5 mg
产品信息
概述| 货号 | 13579-5mg |
| 描述 | Cancer stems cells (CSCs) are a subpopulation of cells within tumors that drive tumor growth and recurrence. They are resistant to many current cancer treatments. Salinomycin (sodium salt) is an antibacterial and coccidiostat compound that shows selective toxicity for the CSCs that exist as a subpopulation within HMLER breast cancer cells (IC50s = ~24 versus ~90 μM).1 At 8 μM, salinomycin treatment of 4T1 and MCF-7-Ras breast cancer cell lines results in a ~2-fold and ~3-fold, respective reduction of CSCs relative to controls.1 Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial differentiation of tumor cells.1 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Gupta, P.B.,Onder, T.T.,Jiang, G., et al. Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138, 645-659 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥90% |
| 计算分子量 | 774 |
| 分子式 | C42H70O11 • Na |
| CAS号 | 55721-31-8 |
| 稳定性 | ≥ 2 years |
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