(R)-Equol
货号：
10010172-1mg 基本售价：
182.0 元 规格：
1 mg
产品信息
概述| 货号 | 10010172-1mg |
| 描述 | Equol is a non-steroidal estrogen produced from the metabolism of the isoflavonoid phytoestrogen daidzein by human intestinal microflora.1,2 It is a chiral molecule that exists in two enantiomeric forms.2 In contrast to the estrogen receptor (ER) selectivity of (S)-equol , (R)-equol is a weaker ER agonist that binds to ERα and ERβ with Ki values of 27.4 and 15.4 nM, respectively.1 The (R)-enantiomer demonstrates higher ER agonist activity at ERα compared to ERβ (EC50 = 66 and 330 nM, respectively).2 |
| 别名 | (+)-Equol;Isoequol; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Setchell, K.D.R.,Clerici, C.,Lephart, E.D., et al. S-equol, a potent ligand for estrogen receptor ß, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora. American Journal of Clinical Nutrition 81, 1072-1079 (2005).
2.Muthyala, R.S.,Ju, Y.H.,Sheng, S., et al. Equol, a natural estrogenic metabolite from soy isoflavones: Convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta. Bioorganic & Medicinal Chemistry 12, 1559-1567 (2004).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 242.3 |
| 分子式 | C15H14O3 |
| CAS号 | 221054-79-1 |
| 稳定性 | ≥ 2 years |
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