| 货号 | 13340-10mg |
| 描述 | As a cofactor of more than 300 enzymes, zinc is integral for a wide variety of cellular processes that affect most biological functions.1 Most notably, its bioavailability is important to the regulation of apoptosis, cell proliferation, and differentiation. TPEN is a cell permeant metal ion chelator that is used in zinc treatment studies to limit intra- and extracellular concentrations of the mineral.2 At a concentration as low as 6 µM, TPEN-induced zinc depletion decreases X-linked inhibitor of apoptosis (XIAP) levels in human PC-3 prostate cancer cells and promotes caspase-3 and -9 activation.3 At 25 µM, TPEN attenuates hypoxic pulmonary vasoconstriction in rodent isolated perfused lung.4 |
| 别名 | TPEDA; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Beyersmann, D. and Haase, H. Functions of zinc in signaling, proliferation and differentiation of mammalian cells. BioMetals 14, 331-341 (2001). 2.Cho, Y.E.,Lomeda, R.A.R.,Ryu, S.H., et al. Cellular Zn depletion by metal ion chelators (TPEN, DTPA and chelex resin) and its application to osteoblastic MC3T3-E1 cells. Nutrition Research and Practice 1, 29-35 (2007). 3.Makhov, P.,Golovine, K.,Uzoo, R.G., et al. Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis (XIAP) and sensitizes prostate cancer cells to TRAIL-mediated apoptosis. Cell Death and Differentiation 15(11), 1745-1751 (2008). 4.Bernal, P.J.,Leelavanichkul, K.,Bauer, E., et al. Nitric oxide mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone. Circulation Research 102(12), 1575-1583 (2008). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 424.6 |
| 分子式 | C26H28N6 |
| CAS号 | 16858-02-9 |
| 稳定性 | ≥ 2 years |
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