| 货号 | 13199-10mg |
| 描述 | Resveratrol is a potent antioxidant found in grapes and red wine that also has anti-proliferative, anti-neoplastic and anti-angiogenic activities. In addition, resveratrol activates sirtuins1 and, in yeast, extends lifespan.2cis-trismethoxy Resveratrol is a potent anti-mitotic drug that is 100-fold more active than resveratrol at inhibiting the growth of human colon cancer Caco-2 cells.3 It inhibits tubulin polymerization in a dose-dependent manner (IC50 = 4 μM) and inhibits enzymes involved in the synthesis of the polyamines, putrescine, and spermidine.3,4trans-trismethoxy Resveratrol has superior pharmacokinetic characteristics when compared with resveratrol, including greater plasma exposure, longer elimination half-life, and lower clearance.5 |
| 别名 | cis-Trimethoxy Stilbene; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Borra, M.T.,Smith, B.C. and Denu, J.M. Mechanism of human SIRT1 activation by resveratrol. The Journal of Biological Chemisty 280(17), 17187-17195 (2005). 2.Howitz, K.T.,Bitterman, K.J.,Cohen, H.Y., et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191-196 (2003). 3.Schneider, Y.,Chabert, P.,Stutzmann, J., et al. Resveratrol analog (Z)-3,5,4-trimethoxystilbene is a potent anti-mitotic drug inhibiting tubulin polymerization. International Journal of Cancer 107, 189-196 (2003). 4.Cushman, M.,Nagarathnam, D.,Gopal, D., et al. Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. Journal of Medicinal Chemistry 34, 2579-2588 (1991). 5.Lin, H.S. and Ho, P.C. A rapid HPLC method for the quantification of 3,5,4-trimethoxy-trans-stilbene (TMS) in rat plasma and its application in pharmacokinetic study. Journal of Pharmaceutical & Biomedical Analysis 49, 387-392 (2009). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 270.3 |
| 分子式 | C17H18O3 |
| CAS号 | 94608-23-8 |
| 稳定性 | ≥ 6 months |
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