| 货号 | 10566-1mg |
| 描述 | Garcinol is an inhibitor of the histone acetyltransferases (HATs) p300 and PCAF (IC50 = 7 and 5 μM, respectively).1 It also inhibits the HAT GCN5 in Cryptococcus neoformans, inducing temperature sensitivity and impairing growth.2 A polyisoprenylated benzophenone isolated from Garcinia indica, garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.3,4 Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions.5,6 |
| 别名 | Camboginol; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Balasubramanyam, K.,Altaf, M.,Varier, R.A., et al. Polyisoprenylated benzophenone, garcinol, a natural histone acetyltransferase inhibitor, represses chromatin transcription and alters global gene expression. The Journal of Biological Chemisty 279(6), 33716-33726 (2004). 2.OMeara, T.R.,Hay, C.,Price, M.S., et al. Cryptococcus neoformans histone acetyltransferase Gcn5 regulates fungal adaptation to the host. Eukaryot.Cell 9(8), 1193-1202 (2010). 3.Weng, M.S.,Liao, C.H.,Yu, S.Y., et al. Garcinol promotes neurogenesis in rat cortical progenitor cells through the duration of extracellular signal-regulated kinase signaling. Journal of Agricultural and Food Chemistry 59, 1031-1040 (2011). 4.Nishino, T.,Wang, C.,Mochizuki-Kashio, M., et al. Ex vivo expansion of human hematopoietic stem cells by garcinol, a potent inhibitor of histone acetyltransferase. PLoS One 6(9), 1-9 (2011). 5.Prasad, S.,Ravindran, J.,Sung, B., et al. Garcinol potentiates TRAIL-induced apoptosis through modulation of death receptors and antiapoptotic proteins. Molecular Cancer Therapeutics 9(4), 856-868 (2010). 6.Koeberle, A.,Northoff, H., and Werz, O. Identification of 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 as functional targets of the anti-inflammatory and anti-carcinogenic garcinol. Biochemical Pharmacology 77(9), 1513-1521 (2009). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 602.8 |
| 分子式 | C38H50O6 |
| CAS号 | 78824-30-3 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |