| 货号 | 10010948-1mg |
| 描述 | Hydrogen sulphide (H2S), a naturally occurring gasotransmitter, is a potent vasodilator and pro-inflammatory mediator.1 DL-Propargyl glycine (PAG) is an irreversible inhibitor of the H2S synthesizing enzyme cystathionine-γ-lyase (CSE). PAG blocks H2S synthesis activity in rat liver preparations with an IC50 value of 55 µM and abolishes the rise in plasma H2S in anaesthetized rats induced with hemorrhagic shock.2 At concentrations ranging from 25-100 mg/kg, PAG can reduce H2S-associated inflammation in rodent models of pancreatitis, oedema, and endotoxemia.3,4,5 |
| 别名 | PAG; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Li, L., and Moore, P.K. Putative biological roles of hydrogen sulfide in health and disease: A breath of not so fresh air? Trends in Pharamacological Sciences 29(2), 84-90 (2007). 2.Mok, Y.Y.P.,Atan, M.S.B.M.,Ping, C.Y., et al. Role of hydrogen sulphide in haemorrhagic shock in the rat: Protective effect of inhibitors of hydrogen sulphide biosynthesis. British Journal of Pharmacology 143, 881-889 (2004). 3.Bhatia, M.,Sidhapuriwala, J.N.,Ng, S.W., et al. Pro-inflammatory effects of hydrogen sulphide on substance P in caerulein-induced acute pancreatitis. Journal of Cellular and Molecular Medicine 12(2), 580-590 (2008). 4.Bhatia, M.,Sidhapuriwala, J.,Moochhala, S.M., et al. Hydrogen sulphide is a mediator of carrageenan-induced hindpaw oedema in the rat. British Journal of Pharmacology 145, 141-144 (2005). 5.Collin, M.,Anuar, F.B.M.,Murch, O., et al. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. British Journal of Pharmacology 146, 498-505 (2005). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 149.6 |
| 分子式 | C5H7NO2 • HCl |
| CAS号 | 16900-57-5 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |