Colchicine
货号：
9000760-100mg 基本售价：
154.0 元 规格：
100 mg
产品信息
概述| 货号 | 9000760-100mg |
| 描述 | Colchicine inhibits microtubule polymerization (IC50 = 3.2 μM) by binding to tubulin, which disrupts spindle formation during mitosis.1 Since increased rate of mitosis is associated with cancer cell proliferation, blocking microtubule function with colchicine has been used as an approach to anti-cancer therapy. For instance, colchicine blocks the growth of MCF-7 human breast carcinoma cells with an IC50 value of 13 nM.1 Its mitosis-inhibiting function is also utilized to perform karyotypes in genetic studies. Colchicine produces anti-inflammatory effects by inhibiting neutrophil motility and activity (5 μmol/kg in a mouse model of gouty arthritis) and inhibits the deposition of uric acid, a key aspect in the treatment of gout.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Martino, G.D.,Regina, G.L.,Coluccia, A., et al. Arylthioindoles, potent inhibitors of tubulin polymerization. Journal of Medicinal Chemistry 47, 6120-6123 (2004).
2.McCarty, D.J. Urate crystals, inflammation, and colchicine. Arthritis and Rheumatism 58(2), S20-S24 (2008).
3.Chia, E.W.,Grainger, R. and Harper, J.L. Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthrities: a rationale for use of low-dose colchicine. British Journal of Pharmacology 153(6), 1288-1295 (2008).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 399.4 |
| 分子式 | C22H25NO6 |
| CAS号 | 64-86-8 |
| 稳定性 | ≥ 2 years |
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